"It is with a profoundly heavy heart that we report that this morning we lost Cameron," said a spokesperson on behalf of the family.
"He passed away in his sleep due to a seizure which was a result of an ongoing medical condition for which he was being treated. The world is now undoubtedly without one of its brightest lights, but his spirit will live on through the kindness and compassion of all who knew and loved him.
"We are utterly heartbroken and ask for privacy during this immensely difficult time as we grieve the loss of our precious son and brother."
Boyce led a humble life, dedicated himself to charity in his most recent years.
Last year he was honoured with the Pioneering Spirit Award at the Thirst Gala, which is sponsored by the Thirst Project - a nonprofit organisation where Boyce raised $30,000 to build wells for clean drinking water in Swaziland.
"From a young age, Cameron Boyce dreamed of sharing his extraordinary artistic talents with the world. As a young man, he was fueled by a strong desire to make a difference in peoples' lives through his humanitarian work," a Disney Channel spokesperson said. "He was an incredibly talented performer, a remarkably caring and thoughtful person and, above all else, he was a loving and dedicated son, brother, grandson and friend.
"We offer our deepest condolences to his family, castmates and colleagues and join his many millions of fans in grieving his untimely passing. He will be dearly missed."
Tributes for the late star have been rolling in since the news was announced.
May he rest in peace.